Autoimmune Hepatitis
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1 minute
Autoimmune hepatitis formerly called Lupoid hepatitis causes liver cirrhosis and can be identified on antibody profile given below. In most questions’ liver biopsy finding of Interface hepatitis and rosette formation is mentioned making it easier but differentiating type 1 vs type 2 is always a challenge and this article serves to simplify it
| Type 1 Autoimmune hepatitis Mnemonic: Smooth Soluble AX effect | Type 2 Autoimmune hepatitis
|
| Anti-Smooth muscle antibody Anti-Soluble liver antigen Atypical p-ANCA/ X-ANCA
| Anti LKM antibody (For type 2 antibody seen is LKM1 and not LKM2) ANA negative Anti-Liver Cytosol antibody
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Extra- mile Histopathology findings
| Primary sclerosing cholangitis | Onion skin fibrosis in bile ducts |
| Primary biliary cirrhosis | Florid duct lesion |
| Autoimmune hepatitis | Rosette formation |