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The revised Mayo Clinic criteria for Takotsubo cardiomyopathy were developed to improve the accuracy of diagnosing this condition. These criteria were proposed by Mayo Clinic researchers and have been widely adopted in clinical practice. The revised Mayo Clinic criteria for TTCM include:

1. Transient Hypokinesis, Akinesis, or Dyskinesis of the Left Ventricular Mid-Segments with or without Apical Involvement: Echocardiography or other imaging modalities should demonstrate transient wall motion abnormalities in the left ventricle, typically involving the mid-segments with or without apical involvement. The characteristic appearance is akin to a Japanese octopus trap (Takotsubo).
2. Absence of Obstructive Coronary Artery Disease or Angiographic Evidence of Acute Plaque Rupture: Coronary angiography should reveal no significant obstructive coronary artery disease or evidence of acute plaque rupture that would explain the extent of myocardial dysfunction observed.
3. New ECG Changes (ST-Segment Elevation and/or T-Wave Inversion) or Troponin Elevation: ECG findings may mimic those of acute coronary syndrome, such as ST-segment elevation or T-wave inversion, but without corresponding coronary artery occlusion. Elevated levels of cardiac biomarkers, such as troponin, may also be present, indicating myocardial injury.
4. Absence of Pheochromocytoma and Myocarditis: Other potential causes of acute myocardial dysfunction, such as pheochromocytoma or myocarditis, should be considered and excluded based on clinical assessment and diagnostic tests.
5. Recovery of Left Ventricular Dysfunction Within a Short Time Frame: The characteristic feature of TTCM is the transient nature of left ventricular dysfunction, with recovery typically occurring within weeks to months.